Polonez BIS

POLONEZ BIS

PROJECT TITLE: „Enzyme Responsive Nanoscale Supramolecular Capsules with Application in Anticancer Drug Delivery”
PROJECT ACRONYM: ERNS Cap
PROJECT ID: 2022/45/P/ST4/00989
PROJECT IMPLEMENTATION TIME: 01.10.2023-30.09.2025


ABOUT PROJECT:
Cancer remains one of the leading causes of death worldwide, yet despite significant research investment a conventional chemotherapeutic has yet to be reported that does not suffer from side effects attributed to the non-selective delivery of the anticancer agent to both healthy and cancerous cells. We aim to develop molecular containers capable of encapsulating commonly prescribed chemotherapeutics. In their encapsulated form the anticancer agents would been unable to interact with key biological agents and thus would not be expected to display toxicity or anticancer activity. Rapid degradation of the capsule in response to elevated levels of enzymes and biomolecules that have been identified as cancer markers would result in the release of the anticancer agent and provide an unexplored methodology for the selective release of active anticancer drugs in cancer cells. The development of a selective method for the delivery of anticancer agents to tumor cells would result in a significant increase in the quality of life for patients receiving anticancer drugs.

RESARCH GROUP INFORMATION:

dr Venkateswarulu Mangili
PRINCIPAL INVESTIGATOR

Center for Advanced Technology
Adam Mickiewicz University in Poznań
https://orcid.org/0000-0002-5016-4666

Address:
ul. Uniwersytetu Poznańskiego 10,
61-614 Poznań, Poland
Office: B230
e-mail: venkateswarulu.mangili@amu.edu.pl
Phone: +48 61 829 18 84
Labs: B231, B235

MSc Agnieszka Bajer
PhD Student
e-mail: agnieszka.bajer@amu.edu.pl

 

Host, Prof. dr hab. Artur R. Stefankiewicz
PROFESSOR

Center for Advanced Technology
Adam Mickiewicz University in Poznań
https://orcid.org/0000-0002-6177-358X

Address:
ul. Uniwersytetu Poznańskiego 10,
61-614 Poznań, Poland
Office: D217
e-mail: ars@amu.edu.pl
Phone: +48 61 829 19 11
Labs: B231, B235

MSc Sidharth Walia
PhD Student

This research is part of the project No. 2022/45/P/ST4/00989 co-funded by the National Science Centre and the European Union Framework Programme for Research and Innovation Horizon 2020 under the Marie Skłodowska-Curie grant agreement no. 945339.

News

25-30 May 2025

  • Artur, Agnieszka, and Venkateswarulu attended ISMSC 2025 in Kyoto, Japan. Prof. Artur delivered a talk on amino acid-based self-assembled nanostructures, while Agnieszka and Venkateswarulu presented a poster on their work with metal–organic cages, which we hope to share with you soon!

 

 

  • Venkateswarulu awarded the Best Poster Prize at ISMSC 2025, held in Kyoto, Japan.


July- August 2025

  • We had an interview with Ewa Konarzewska-michalak, Życie Uniwersyteckie. See the university Blog  [LINK]

15 April 2025

  • Discussed scientific topics and presented the POLONEZ BIS project titled ‘Enzyme-Responsive Nanoscale Supramolecular Capsules with Application in Anticancer Drug Delivery’ with Prof. James E. M. Lewis (Associate Professor at the University of Birmingham), during his visit to Adam Mickiewicz University in Poznań as part of the ID-UB UAM project, AMU Excellence Visiting Professors, where he delivered a lecture.

 

6–9 October 2024

    • Artur and Venkateswarulu attended the 13th International Symposium on Nano & Supramolecular Chemistry (ISNSC 2024) held in Sardinia, Italy. Prof. Artur delivered a talk on Amino acid-based self-assembled nanostructures, while Venkateswarulu presented a poster on his work with water-soluble chiral metal–organic cages.

02-06 September 2024

  • Agnieszka attended the 17th International Seminar on Inclusion Compounds and Porous Materials (17 ISIC) held in Poland. Congratulations to Agnieszka on being awarded the Best Poster Prize at the 17 ISIC!

November 2023

  • Ph.D. competition for two students is completed.

30 November-1 December 2023

  • We joined the Polonez Bis kick-off meeting with Agnieszka Jędrzejczyk.